CRISPR Gene Editing Technique Used In Creating HIV Immune Twin Sisters

Chinese medical officials are investigating the scientist who claims to have created the world’s first genetically-edited babies. He Jiankui said the twin sisters were born with immunity to HIV, the virus that causes AIDS. He claims he altered their DNA in a lab using a gene editing technique called CRISPR.

The controversial research was roundly condemned because it was shrouded in secrecy and broke with international scientific norms. But He said his breakthrough can protect children from a dangerous and deadly disease, and that he’s on the right side of history.

The technology to genetically edit human embryos has been around for a while, but scientists were unwilling to cross that ethical line. He, a Stanford and Rice University trained physicist, said he used the technique CRISPR to help a married Chinese couple conceive twins immune to HIV.

“I believe families need this technology. And I’m willing to take the criticism for them,” He said.

When the girls were still embryos, he used chemical “scissors” to turn off a gene that makes people vulnerable to HIV infection. The embryos were then implanted into the mother who gave birth to Lulu and Nana earlier this month.

“No gene was changed except the one to prevent HIV infection. The girls are safe, healthy as any other babies,” He said.

China’s National Health Commission ordered an investigation into He’s work, which defied a global scientific consensus banning the use of genetic editing on human embryos.

He’s university in China, where he was on unpaid leave, said it was “deeply shocked” by his research, which it believes “seriously violated academic ethics and codes of conduct.”

Kiran Musunuru, an associate professor of medicine at the University of Pennsylvania, believes this was an attempt to engineer genetically modified human beings.

“I think this was irresponsible,” Musunuru said. “No question that that is unethical. I would actually add immoral to that.”

Musunuru reviewed some of he’s scientific data and said he believes the genetic edits on the embryos were incomplete, meaning the girls may not be totally immune to HIV. Musunuru also said there’s evidence other genes were edited unintentionally, potentially increasing the twins’ risk for cancer.

“Taking those embryos forward through pregnancy to live children, to me, is absolutely appalling and horrifying. I can’t imagine why anyone with any sort of compassion would actually do that,” Musunuru said.

He will formally present his findings Wednesday at a scientific conference in Hong Kong. Rice University said the work described violates conduct guidelines of the scientific community and launched an ethics investigation into Michael Deem, a bioengineering professor who was part of He’s research team.

There are rules against this kind of experimentation in the U.S. and Europe, but not in China. The hope is the strong reaction from the scientific community, coupled with various investigations that have been opened, can be a deterrent.

Reference

Global outrage after Chinese researcher claims first gene-edited babies

Chinese Scientist Defends Creating Gene Edited Twin Sisters

Laptop Cooling Pad Market Analysis Overview

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Worldwide Laptop Cooling Pad Market: Forecast Highlights: The examination report covers future market projections of the worldwide market for workstation cooling cushions. The present situation uncovers a valuation of around US$ 270 Mn (in 2018). This situation is relied upon to ascend to achieve a higher estimation of more than US$ 430 Mn before the year’s over of gauge (2025). The worldwide PC cooling cushion advertise is anticipated to develop at a high CAGR of 5.9% all through the time of gauge, 2018-2025.

 Worldwide Laptop Cooling Pad Market: Growth Influencing Aspects: Adoption of preventive measures to evade workstation untimely disappointment, expanding import and fare of electronic merchandise, ceaseless utilization of PCs in a few industry verticals, expanded selection of PCs for gaming purposes combined with a blast in the gaming business, expanded reception of PC frill, government activities to advance the assembling area and rising extra cash and diminishing normal offering cost have impelled the development of the worldwide PC cooling cushion market. However, expanded market entrance of cell phones and tablets, high import taxes and charges on purchaser electronic products, surprising expense of PC cooling cushions, nonstandard items corrupting item quality and constrained mindfulness about cutting edge innovations are the difficulties that are restricting the development of the worldwide PC cooling cushion advertise.

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Worldwide Laptop Cooling Pad Market: Segmental Snapshot: The worldwide workstation cooling cushion advertise is divided based on item write, deals channel, end client and district. As for district, North America reflects high lucrativeness for the development of the worldwide market for workstation cooling cushions. The workstation cooling cushion showcase in this district is foreseen to develop at a high CAGR of 6.8% to achieve a valuation of more than US$ 150 Mn before the year’s over of evaluation. By deals channel, the internet business/online fragment is relied upon to overwhelm the worldwide market with a high market valuation and development rate.

The main points which are answered and covered in this Report are-

What will be the total market size in the coming years till 2025?

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Will your laptop cooling pad be for work or home use?

Gamers tend to drive their laptops hard, so lots of cooling pads are designed with this market in mind – which means grungy colour schemes and jazzy LED lights. Whichever pad you’re interested in, think about whether its design is appropriate for where you’ll be using it: if your pad is coming to work with you, you might want to look for a sober, professional-looking model.

Reference

Laptop Cooling Pad Market Analysis

Laptop Cooling Pad For Home And Office

Chief Business Officer of Whatsapp Resigns

Roughly one year after WhatsApp  co-founder Brian Acton  made his highly-publicized exit from Facebook, another executive and early employee of the messaging platform is doing the same. Neeraj Arora, WhatsApp’s chief business officer, announced today that he would be “taking some time off to recharge and spend time with family.”

Facebook  acquired WhatsApp for $19 billion in 2014 and pledged to allow the messaging giant to continue to operate independently under Acton and co-founder Jan Koum, who served as its chief executive officer until abruptly quitting over privacy and data concerns in April. Arora, who joined WhatsApp in 2011 from Google, was rumored to be the frontrunner to replace Koum as CEO. With him out the door, it’s unclear who will be tapped to lead WhatsApp .

In today’s announcement, Arora said he was “deeply indebted” to both Acton and Koum, “who entrusted me to be their business companion for so many years.”

Facebook subsidiaries WhatsApp and Instagram  are both in periods of flux following the exits of their original founders, which are believed to be caused by quarrels with the social media giant’s CEO Mark Zuckerberg .

In what was one of the largest tech stories of 2018, Instagram co-founders Kevin Systrom  and Mike Krieger  announced they were leaving Facebook years after the company acquired their photo-sharing app for $1 billion. They shared the news in September, just a few months after Koum stepped down from WhatsApp.

According to The New York Times, Zuckerberg, over the course of the last year, had begun to assert more and more control over Instagram, upsetting its leaders.

Koum, for his part, reportedly wrote in a since-removed WhatsApp blog post that Zuckerberg and Facebook no longer had respect for privacy: “These days companies know literally everything about you, your friends, your interests, and they use it all to sell ads. At every company that sells ads, a significant portion of their engineering team spends they day tuning data mining, writing better code to collect your personal data… remember, when advertising is involved, you the user are the product.”

According to TechCrunch’s Josh Constine, Koum was unhappy “about how Facebook would monetize his app and the impact of that on privacy.” Both Acton and Koum departed Facebook before they fully vested from the multi-billion acquisition, meaning the pair chose to lose hundreds of millions of dollars over continued employment at Facebook.

Arora’s exit is further evidence that Facebook has entered a new era, one in which the company’s acquisition strategy may be in serious danger of long-term damage.

Reference

Chief Business Officer Leaves WhatsApp

Samsung Galaxy Note 9 Has A New Snow White Color Varaint

The Taiwan branch of Samsung Electronics has just announced what is roughly translated as a “First Snow White” version of its popular Galaxy Note9. The new color is timed to welcome the winter season, and for the time being it’s not only a Taiwan exclusive, but sale is limited to just a handful of stores in the country.

Precise details about the launch are difficult to determine, given the original press release was in Chinese (and the translated version has some pretty strange statements to make about flywheels), but we do know what it looks like. In images published to the Samsung Taiwan Facebook page, we can see that the back is a solid and bright white, as are the fingerprint sensor and sections of the raised camera assembly. Based on what little is visible of the edges, it appears to be complemented by a matte silver anodized aluminum frame.

Currently, the “First Snow White” is set to be an exclusive for Taiwan, but it’s possible (and we’re hopeful) that it could come to more markets in the future. In the meantime, those in Taiwan looking to pick one up will be paying NT$30,900 for the 128GB model, which works out to a few cents below a round $1,000 USD. 

The original PR for Samsung’s announcement is available here, but we’ve embedded Google’s (occasionally hilarious) translation below in the reference link.

Reference 

Galaxy Note9  has a snow white color for Taiwan